Any new formulation that could effectively serve as a targeted therapy system is desirable. The widespread use of emulsions in pharmaceutical and cosmetic technology stems from their ability to simultaneously deliver compounds of varying polarity. However, a key limitation of these systems remains their low physical stability, resulting from the thermodynamic tendency for phase separation. In the search for more stable carriers of active substances, the concept of emulgels has been developed—hybrid systems combining the characteristics of gels and emulsions. These formulations have attracted particular attention in topical applications due to their excellent sensory properties, such as a light texture and rapid absorption, without the undesirable greasiness. Importantly, the structure of emulgels allows precise control over the release profile of active ingredients.

The aim of the present study was to evaluate novel cholesterol-based surfactants in terms of their ability to stabilize emulgels. The study consisted of two main stages. The first stage involved determining the surface activity of the synthesized compounds to verify their behavior as classical surfactants. The second stage focused on the application of these compounds as emulgel stabilizers. To validate the formulations, stability tests were performed, microbiological purity was assessed, and key physicochemical properties, such as density and pH, were determined.

The results confirmed that the synthesized cholesterol derivatives exhibit high surface activity and can be successfully applied as effective stabilizers in emulgel systems. The resulting formulations demonstrated high physical stability and desirable physicochemical parameters, making them a promising alternative to classical topical systems.