OBJECTIVE
Biomimetic growth factors are of increasing interest in cosmetic science due to their roles in skin regeneration and tissue homeostasis. However, their wider application has been limited by poor protein stability and inefficient delivery across the stratum corneum. This work evaluates a plant-produced oleosome–growth factor fusion technology designed to enhance protein stability and bioavailability in cosmetic formulations and explores its extension into scalp and haircare applications. The sustainability performance of this plant-based production system is also assessed.
MATERIALS & METHODS
Human-identical epidermal growth factor (EGF) and fibroblast growth factor-2 (FGF-2) were expressed in Camelina sativa seeds as fusions with native oleosome structures. Oleosome–protein complexes were isolated using aqueous, low-energy processing without organic solvents. Protein stability was assessed under accelerated storage conditions. Independent clinical studies in human subjects evaluated topical formulations containing oleosome–growth factor fusions. Skincare studies assessed wrinkles, firmness, pigmentation, and barrier-related parameters over 14 days, including comparative evaluation versus retinol. A separate clinical study evaluated an oleosome–FGF-2 fusion in haircare applications, measuring scalp condition and hair parameters. Sustainability performance was assessed using third-party environmental, social, and governance (ESG) rating frameworks, including EcoVadis.
RESULTS
Oleosome–growth factor fusions showed significantly improved protein stability compared to non-fused growth factors. Skincare studies demonstrated visible improvements in wrinkles, firmness, pigmentation, and barrier-related parameters within 14 days, with performance comparable to or exceeding retinol-based formulations and good tolerability. In haircare applications, treatment with an oleosome–FGF-2 fusion resulted in measurable increases in hair density, hair shaft thickness, and hair growth–related parameters. Independent ESG assessment ranked the production system among the highest-performing globally.
CONCLUSION
Plant-derived oleosome–growth factor fusion technology provides an effective strategy to improve the stability and delivery of biomimetic proteins in cosmetic applications, combining clinically relevant efficacy with independently validated, low-impact plant-based production and demonstrating potential for both skincare and haircare use.